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Danheiser benzannulation : ウィキペディア英語版 | Danheiser benzannulation
The Danheiser Benzannulation is a chemical reaction used in organic chemistry to generate highly substituted phenols in a single step. It is named after its inventor, Dr. Rick Danheiser. ==Annulation==
An annulation is defined as a transformation of one or more acyclic precursors resulting in the fusion of a new ring via two newly generated bonds.〔IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8.〕 These strategies can be used to create aromatic systems from acyclic precursors in a single step, with many substituents already in place.〔Danheiser, R L., Brisbois, R G. James, J. Kowalczyk, Miller, R. F. “An Annulation Method for the Synthesis of Highly Substituted Polycyclic Aromatic and Heteroaromatic Compounds.” J. Am. Chem. Soc. 1990, 112, 3093-3100.〕 A common synthetic annulation reaction is the Robinson annulation. It is a useful reactions for forming six-membered rings and generating polycyclic compounds. It is the combination of the Michael Addition and the Aldol Condensation reaction.〔"(Robinson Annulation )." Organic-Chemistry. Organic Chemistry Portal, Web. 06 Nov. 2014.〕
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